© Borgis - Postępy Nauk Medycznych 9/2012, s. 684-688
Krzysztof Adamowicz1, Wanda Knopińska-Posłuszny2, *Jan Maciej Zaucha3
Jednoczesne wystąpienie transformacji przewlekłej białaczki limfocytowej do chłoniaka Hodgkina i raka płuca – opis przypadku i przegląd literatury
Concomitant occurrence of Hodgkin variant of Richter syndrome and a lung cancer in a patient with CLL – a case report and review of the literature
1Regional Oncology Center, Gdańsk
Director: Ewa Solska, MD
2Department of Haematology and Transplantology, Medical University of Gdańsk
Head of Department: prof. Andrzej Hellmann, MD, PhD
3Department of Propedeutic Oncology, Faculty of Health Science, Medical University of Gdańsk
Head of Department: Wiesław Janusz Kruszewski, MD, PhD, associate professor
Przewlekła białaczka limfatyczna (CLL) przebiega stabilnie przez okres od wielu miesięcy do wielu lat. U niewielkiego odsetka przypadków może jednak przekształcić się do bardziej agresywnych typów chłoniaków. Pojawienie się objawów systemowych, takich jak utrata masy ciała, gorączka lub miejscowych pod postacią szybko narastającej organomegalii u chorego z CLL budzi podejrzenie transformacji w chłoniaka o wysokim stopniu złośliwości, zwanej zespołem Richtera. Podobne objawy mogą pojawić się w przypadku drugiego nowotworu, którego ryzyko rozwoju u chorych z CLL jest o 10-20% wyższe niż w zdrowej populacji. Poniżej przedstawiamy przebieg kliniczny, trudności diagnostyczne i terapeutyczne u 59-letniego pacjenta, który równocześnie rozwinął niedrobnokomórkowego raka płuca i transformację do chłoniaka Hodgkina (HL) dwa lata po rozpoznaniu CLL. Dodatkowo omówiono epidemiologie i przebieg kliniczny transformacji CLL do chłoniaka Hodgkina, a także aberracje genetyczne występujące wspólnie w rozwoju raka płuca i CLL.
Chronic lymphocytic leukaemia (CLL) is usually stable over months to years however a small proportion of cases may transform to more aggressive types of lymphomas. Development of systemic symptoms such as losing weight, fever or local symptoms such as rapidly growing organomegaly in a patient with CLL suggests transformation to high grade lymphoma known as Richter’s syndrome. Similar symptoms can occur in case of second malignancy, which incidence in patients with CLL is 10-20% higher compared to normal population. Here we present a clinical course, diagnostic and therapeutic difficulties in 59-year old patient who simultaneously developed non small cell lung cancer and transformation to Hodgkin lymphoma (HL) 2 years after the diagnosis of CLL. The epidemiology and clinical course of Hodgkin variant of Richter syndrome as well the genetic aberrations possibly shared in development of CLL and lung cancer have been discussed.
The course of B-cell chronic lymphocytic leukaemia (CLL) is variable: indolent in about one third of patients never requiring treatment. Approximately one-third represents an initially indolent disorder that progresses and requires therapy within 5 years after diagnosis. In remaining patients CLL is more aggressive disease requiring treatment but disease still maintains its characteristic phenotype (1).
However a small proportion of cases even with an indolent disease may transform to high grade aggressive lymphomas (2) first described in 1928 by Maurice N. Richter (3) who reported a case of a 46-year-old man with diffuse lymphadenopathy, massive organomegaly and a rapidly fatal clinical course as seen in untreated diffuse large B-cell lymphoma (DLBCL). Patients with Richter transformation (RT) typically present with constitutional symptoms (lost of weight, fever), rapidly enlarging lymph nodes, spleen or liver and increased lactate dehydrogenase (LDH) activity with histological features of DLBCL that are formally required to make a diagnosis of RT (4). The current estimated rate of Richter transformation in CLL is approximately 2-8% (4, 5). Although the most common type of histological transformation of CLL is to a high-grade B-non-Hodgkin lymphoma (NHL), other types of lymphomas have also been described, including Hodgkin lymphoma (6), small noncleaved cell lymphoma (7), lymphoblastic lymphoma (8), hairy cell leukaemia (9), and high-grade T-cell NHL (10, 11). Transformation of CLL/SLL to Hodgkin lymphoma, called ”Hodgkin variant of Richter transformation (HLvariantRT) occurs very rarely (0.5% of patients with CLL/SLL) constituting 15% of RT. (6, 12-14) Although rare, it is considered one of the commonest second malignancies in patients with a known CLL. Increased risk of developing Hodgkin lymphoma among CLL patients when compared with the general population, with an observed-to-expected ratio of 7.69 was reported by Travis et al. (15).
Patients with CLL have also an increased risk (20%) of second malignancy compared to general population (15, 16). Significantly increased risks were observed for Kaposi sarcoma, malignant melanoma and cancers of the larynx and the lung (16). Presentation of second malignancy in patients with CLL may mimic RT symptoms causing delay in correct diagnosis, thus decreasing a chance of early intervention. Here we describe diagnostic and therapeutic difficulties in a 59-year old patient with CLL, who almost simultaneously developed non small cell lung cancer and Hodgkin variant of Richter syndrome two years after the diagnosis of CLL.
A 59-year old patient with a history of smoking, arterial hypertension, ischaemic heart disease and numerous ischaemic foci in the brain was referred in September 2005 to the haematology department because of leucocytosis combined with night sweats and general asthenia. Physical examination revealed generalised enlargement of peripheral lymph nodes (approx. 2 cm), mainly cervical and axillary without enlargement of the spleen and liver. Blood cell count showed leucocytosis (85 x 109/l) composed mainly of mature lymphocytes, anaemia (Hb approx. 10 g/dl) and thrombocytopenia (98 x 109/l). Imunophenotyping of lymphocytes was consistent (CD5(+)CD19(+)) with diagnosis of B-cell chronic lymphocytic leukaemia. The patient was started on chlorambucil, and achieved after 12 months a partial remission (reduction of leucocytosis and lymphocytosis to 16.6 and to 14.9 x 109/l, respectively, increase of Hb and platelets up to 13.3 g/dl and to 123 x 109/l, respectively) with resolution of systemic symptoms.
In February 2007 on physical examination, the patient was found an oedema of the left lower extremity, followed few days later by diarrhoea and fever of up to 39°C with shivers. The patient was admitted to the department for internal medicine. His WBC was stable (14.82 x 109/l, lymphocytosis 6.84 x 109/l) and haemoglobin and platelets were within normal range. Chest X-ray revealed a round lesion of approx. 15 mm in the right apex of the lung and a polycyclic right hilum of the lung. Radiographic evaluation including comparison with prior films suggested that the lesion in the apex of the right lung might be related to a putative past tuberculosis, whereas a widening of pulmonary hilum to the primary disease. Doppler test of deep veins in the left lower extremity indicated thrombosis in the sagittal vein, 1/2 of the distal femoral vein and popliteal veins. Following an antithrombotic therapy and administration of antibiotics, oedema of the left lower extremity disappeared with concomitant improvement of the patient’s general condition. Chlorambucil and prednisone were re-introduced. The patient received two subsequent cycles and his general condition remained stable.
In April 2007 the patient reported numbness of the right upper extremity, pain of the right shoulder, itching, fever and dyspnoea leading to admission to the Department for Lung Diseases. Computed tomography of the chest and the abdominal cavity revealed bilateral pulmonary embolism and a concomitant lesion in the 2nd segment of the right lung (57 x 37 mm, fig. 1), with a rib destruction at that level and numerous enlarged lymph node groups – mediastinal, hilar, retroperitoneal and iliac.
Fig. 1. Computed tomography scan of the 2nd segment of the right lung with a tumour (T) and associated rib destruction with enlargement of adjacent lymph nodes (N) in a CLL patient with Hodgkin variant of Richter transformation and concomitant lung cancer.
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