*Konrad Wroński1, Przemysław Stefaniak2, Zbigniew Masłowski2, Leszek Frąckowiak1
Cutaneous Kaposi sarcoma – case report
1Department of Oncology, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland
Head of Department: prof. Sergiusz Nawrocki, MD, PhD
2Department of Surgical Oncology, Hospital Ministry of Internal Affairs with Warmia and Mazury Oncology Centre, Olsztyn, Poland
Head of Department: Andrzej Lachowski, MD
Classic Kaposi sarcoma is rare disease. First time it was described by Moriz Kaposi in 1872 as an idiopathic, multipigmented sarcoma of the skin. Typically, classic Kaposi sarcoma is observed in men from Sub-Saharan Africa, Eastern Europe or Middle Eastern descent. It is rare observed in North America and Northern Europe. Surgical biopsy is important in diagnosis of this neoplasm. Every patient with Kaposi sarcoma must have HIV test done. Treatment of Kaposi’s sarcoma evaluated from classic form for single lesion to experimental therapies. For patients with single lesion surgical biopsy is adequate treatment. Patients with a few lesions located nearby can be treated by single doses of radiation (from 8 to 12 Gy). Patients with widespread mucocutaneous disease, lymphedema or visceral disease are treated with systemic cytotoxic therapy. In this article the authors presented a case of a man who was admitted to the hospital because of classic cutaneous Kaposi sarcoma. The patient underwent surgery of the biggest skin tumor located in the left inguinal area which disturbed function normally every day.
Kaposi sarcoma it is relatively rare disease in the world. This disease was first time described in 1872 as an idiopathic, multipigmented sarcoma of the skin (1). Typically, classic Kaposi sarcoma is observed in men from Sub-Saharan Africa, Eastern Europe or Middle Eastern descent (2, 3). It is rare that patient suffer from multifocal lesions in one leg. The authors of this article presented such HIV-negative patient.
A 60-year-old man, Caucasian race, was admitted to the Department of Surgical Oncology because of diagnosed cutaneous Kaposi sarcoma of the left leg and skin tumor in left inguinal area. In an interview with the patient, he informed us that tumor on the left leg was present for 3 months and gradually expanded. The patient reported no pain in this area. Surgical biopsy showed Kaposi sarcoma.
He had no any other symptoms, there was no history of weight loss and loss of appetite. The patient was not treated for chronically diseases. He had no surgeries before and there was no history of carcinoma in patient family. Blood test and other routine hematological examinations and biochemical tests were within normal limits. He was not HIV positive patient.
On physical examination, whole the left leg was with tumors (fig. 1 and 2). There were not enlarged inguinal lymph nodes. Also ultrasound examination of the inguinal lymph nodes did not show pathologically enlarged lymph nodes.
Fig. 1. Cutaneous Kaposi sarcoma of the left feet.
Fig. 2. Cutaneous Kaposi sarcoma of the left leg.
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1. Kaposi M: Idiopatische multiples Pigmentsarkom der Haut. Arch Dermatol Syph 1872; 3: 265-273. 2. Laor Y, Schwartz RA: Epidemiologic aspects of American Kaposi’s sarkoma. J Surg Oncol 1979; 12: 299-303. 3. Ross RK, Casagrande JT, Dworsky RL et al.: Kaposi’s sarcoma in Los Angeles, California. J Natl Cancer Inst 1985; 75: 1011-1015. 4. Beral V: Epidemiology of Kaposi’s sarcoma. Cancer Surv 1991; 10: 5-22. 5. Beral V, Peterman TA, Berkelman RL et al.: Kaposi’s sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 1990; 335: 123-128. 6. Chang Y, Cesarman E, Pessin MS et al.: Identification of herpesviruslike DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 266: 1865-1869. 7. Brenner B, Rakowsky E, Katz A et al.: Tailoring treatment for classical Kaposi’s sarcoma: comprehensive clinical guidelines. Int J Oncol 1999; 14: 1097-1102. 8. Lo TC, Salzman FA, Smedal MI, Wright KA: Radiotherapy for Kaposi’s sarcoma. Cancer 1980; 45: 684-687. 9. Nisce LZ, Safai B, Poussin-Rosillo H: Once weekly total and subtotal skin electron beam therapy for Kaposi’s sarcoma. Cancer 1981; 47: 640-644. 10. Volberding PA, Abrams DI, Conant M et al.: Vinblastine therapy for Kaposi’s sarcoma in the acquired immunodeficiency syndrome. Ann Intern Med 1985; 103: 335-338. 11. Gill PS, Rarick M, McCutchan JA et al.: Systemic treatment of AIDS related Kaposi’s sarcoma: results of a randomized trial. Am J Med 1991; 90: 427-433. 12. Abrams DI, Volberding PA: Alpha interferon therapy of AIDS-associated Kaposi’s sarcoma. Semin Oncol 1986; 13 (suppl. 2): 43-47. 13. de Wit R, Danner SA, Bakker PJ et al.: Combined zidovudine and interferon-alpha treatment in patients with AIDS-associated Kaposi’s sarcoma. J Intern Med 1991; 229: 35-40. 14. Soler RA, Howard M, Brink NS et al.: Regression of AIDS-related Kaposi’s sarcoma during therapy with thalidomide. Clin Infect Dis 1996; 23: 501-505. 15. Saiag P, Pavlovic M, Clerici T et al.: Treatment of early AIDS-related Kaposi’s sarcoma with oral all-trans-retinoic acid: results of a sequential non-randomized phase II trial. AIDS 1998; 12: 2169-2176.