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© Borgis - New Medicine 1/2005, s. 2-4
Łukasz Ulatowski, Grzegorz Krasowski
Anal fissure
Departament of Surgery, Wolski Hospital,Warsaw, Poland
Head: Marek Kruk MD, PhD
Summary
Anal fissure is a benign condition of the anus, most commonly found in the posterior commissure, causing severe rectal pain and bleeding. In the present paper the authors review the available literature and describe the pathogenesis, manifestations as well as currently employed treatment methods with respect to the division into acute and chronic anal fissures.
INTRODUCTION
Anal fissure is one of the most frequent benign conditions of the anus. Due to its symptoms related to defecation (severe pain, bleeding, pruritus), the fact that it tends to become chronic and troublesome for the patient, as well as a long-term and difficult treatment, the condition still raises a vital concern in modern proctology. The term anal fissure refers to a longitudinal tear in the mucosa of the anoderm and the anal canal, extending from the external anal orifice to the pectinate line. Anal fissure is frequent in young active professional adults; its peak incidence is in the third and fourth decades of life. The general prevalence rate in men and women is similar, however, more men than women are affected in the group under the age of 20 years; in women, the condition is more common at a later age. Anal fissure may also occur in infants; some authors have reported the condition in about 80% of one-year old infants, which, with adequate hygiene, heals spontaneously. Anal fissure does not only produce symptoms, but it may also be an aetiological factor in chronic constipation.
PATHOPHYSIOLOGY
The current approach shows that the condition is caused by an impaired anorectal motor function manifested by, e.g., an exaggerated resting sphincter spasm, a paradoxical sphincter spasm on defecation. This assumption has been confirmed by manometry which shows an increased pressure in the anal canal up to 120mm Hg (reference value approx. 70 mmHg). The abnormality results in an inadequate blood supply to the distal portion of the anal canal with resulting tissue anaemia and susceptibility to trauma. This has been confirmed by an increased blood flow in the anal mucosa after an effective treatment [1]. The theory presented by Gibbons and Read assumes that the fissure formation is mainly due to an impaired motor function of the sphincters. An inflammatory aspect is also worth considering – it accounts for an increased prevalence of anal fissure in patients with persistent diarrhoea. During degradation, perianal and cryptal faecal residue releases irritant substances, which leads to inflammation.
SYMPTOMS AND SIGNS
Severe colicky pain on defaecation, which may persist after the passage of stool, is the main symptom in anal fissure. The pain is due to a strong involuntary spasm of the internal anal sphincter. This may be subsequently followed by difficult defaecation and bleeding from the anus. Mucous and faecal discharge may appear in the course of the disease. The patient experiences a ”wet anus”; occasionally, pruritus may develop. In view of their duration and severity of symptoms, anal fissures are divided into acute and chronic. Diagnosis is not difficult: inspection of the anus reveals a linear tear in the anal mucosa which is most frequently found (75%) at the posterior commissure, in the midline. Anterior anal fissures occur more frequently in women; concomitant posterior and anterior anal fissures are rare. Chronic anal fissures have a typical appearance: a hypertrophied papilla in the dentate line (a sentinel pile) at the lower end, and pale fibres of the internal sphincter, a hypertrophied marginal fold, known as Brodie´s pile, at the upper end. A chronic, painless anal fissure in a lateral location, makes it imperative for the clinician to search for an underlying pathology, e.g., Crohn´s disease or AIDS. In some cases fissure-like lesions are accompanied by a macerated anal verge. Since it is painful, rectal examination and instrumental diagnostic procedures are contraindicated in patients with anal fissure. A thorough proctological examination is performed when the acute stage of the disease has subsided.
TREATMENT

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Piśmiennictwo
1. Schouten WR, Briel JW, Auwerda JJ, De Graaf EJ. Ischaemic nature of anal fissure. Br J Surg. 1996 Jan;83(1):63-5. 2. Jonas M, Speake W, Scholefield JH. Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study. Dis Colon Rectum 2002 Aug;45(8):1091-5. 3.Ansaloni L, Bernabe A, Ghetti R, Riccardi R, Tranchino RM, Gardini G. Oral lacidipine in the treatment of anal fissure. Tech Coloproctol 2002 Sep;6(2):79-82. 4.Bielecki K. Szczelina odbytu-problem proktologiczny. Proktologia pod red. Bieleckiego K. i Dzikiego A. Wydanie I . rozdz. 8:150-155. Wydawnictwo Lekarskie PZWL, Warszawa 2000. 5.Arroyo A, Perez F, Serrano P, Candela F, Calpena R. Long-term results of botulinum toxin for the treatment of chronic anal fissure: prospective clinical and manometric study. Int J Colorectal Dis. 2004 Oct 30; [Epub ahead of print]. 6.Madaliński MH, Sławek J, Dużyński W, Zbytek B, Jagiełło K, Adrich Z, Kryszewski A. Side effects of botulinum toxin injection for benign anal disorders. Eur J Gastroenterol Hepatol 2002 Aug;14(8):853-6. 7.Trzcinski R, Dziki A, Tchorzewski M. Injections of botulinum A toxin for the treatment of anal fissures. Eur J Surg. 2002;168(12):720-3. 8.Lindsey I, Cunningham C, Jones OM, Francis C, Mortensen NJ. Fissurectomy-botulinum toxin: a novel sphincter-sparing procedure for medically resistant chronic anal fissure. Dis Colon Rectum. 2004 Nov;47(11):1947-52. 9.Godevenos D, Pikoulis E, Pavlakis E, Daskalakis P, Stathoulopoulos A, Gavrielatou E, Leppaniemi A. The treatment of chronic anal fissure with botulinum toxin. Acta Chir Belg. 2004 Oct;104(5):577-80. 10.Herman R.M. Szczelina odbytu. Komentarz Medycyna praktyczna Chirurgia. 1999, 1 (13), 133-136 11. Gorfine S.R. Treatment of benign anal disease with topical nitroglicerin. Dis.Colon Rectum. 1995, 38 (5), 453-456. 12.Carapeti E.A., Kamm M.A., McDonald P.J., Chadwick S.J.D. et al. Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective and there is a high recurrence rate. Gut, 1999, 44, 727-730. 13.Griffin N, Zimmerman DD, Briel JW, Gruss HJ, Jonas M, Acheson AG, Neal K, Scholefield JH, Schouten WR. Topical L-arginine gel lowers resting anal pressure: possible treatment for anal fissure. Dis Colon Rectum 2002 Oct;45(10):1332-6. 14.McDonald A., Smith A., McNeill A.D., Finlay I.G., Manual dilatation of the anus. Br J. Surg. 1992, 79, 1381-82. 15.Meier zu Eissen J. Chronic anal fissure, therapy. Kongressbd Dtsch Ges Chir Kongr 2001;118:654-6. 16.Nelson R. Operative procedures for fissure in ano. Cochrane Database Syst Rev 2002;(1):CD002199. 17.Ammari FF, Bani-Hani KE. Faecal incontinence in patients with anal fissure: a consequence of internal sphincterotomy or a feature of the condition? Surgeon. 2004 Aug;2(4):225-9. 18.Gupta PJ. Hypertrophied anal papillae and fibrous anal polyps, should they be removed during anal fissure surgery? World J Gastroenterol 2004; 10(16): 2412-2414. 19.Brisinda G., Maria G., Bentivoglio A.R. et al. A comparison of injections of botulinum toxins and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl. J. Med. 1999, 341, 65-69. 20.Corby H, Donnelly VS, O´Herlihy C, O´Connell PR. Anal canal pressures are low in women with postpartum anal fissure. Br J Surg. 1997 Jan;84(1):86-8. 21.Trzciński R., Dziki A. Szczeliny odbytu - objawy, etiologia i leczenie. Proktologia, Vol. 2 ( 2001), nr 4(5); 337-349.
New Medicine 1/2005
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