© Borgis - New Medicine 3/1999, s. 74-76
Maria Wąsik1, Mieczysław Chmielik2, Małgorzata Kowalska1, Lidia Zawadzka-Głos2, Jolanta Rybczyńska1, Elżbieta Górska1
Disturbances of lymphocyte subpopulations in children with tonsillar hypertrophy
1 Department of Lab. Diagnostics and Clinical Immunology of Developmental Age, The Medical University Warsaw, Poland
Head: Prof. Wąsik Maria, M.D.
2 Pediatric ENT Clinic; The Medical University of Warsaw, Poland
Head: Prof. Chmielik Mieczysław, M.D.
In this study we investigated lymphocyte subsets of peripheral blood and tonsils in children with tonsillar hypertrophy and recurrent tonsillar hypertrophy. Whole peripheral blood taken before and after operation and tonsillar cellular suspension were stained with monoclonal antibodies and analysed by flow cytometry. In both groups there were abnormalities of CD molecule expression of the peripheral blood lymphocytes. Quantitative differences in tonsillar lymphocyte subpopulations between two examined groups were noticed. In two re-operated patients (1 and 2 ) we found remarkable long-term persisting hypoexpression of CD lymphocyte antigens in the peripheral blood. The usefulness of monitored immunostimulating treatment in such patients is discussed.
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