© Borgis - New Medicine 3/1999, s. 66-67
Jarosław Szydłowski1 Ewa Fik2, Michał Grzegorowski1, Anna Goździcka-Józefiak2, Jarosław Antyborzec1, Iwona Steiner1
The incidence of Chlamidia pneumoniae co-infection in children infected with HPV
1 ENT Department, Paediatric Institute of the Karol Marcinkowski University of Medical Sciences in Poznań, Poland
Head of ENT Department: Prof. Michał Grzegorowski, M.D.
2 Department of Molecular Virology, A. Mickiewicz University
Head of Department: Prof. Anna Goździcka-Józefiak
Little is know about HPV and Ch. pneumoniae co-infection in the upper respiratory tract of healthy children. A group of 49 HPV positive children (from 3 to 6 years old) was laryngologically examined. Smers from noses and throats were studied for the presence of Ch. pneumoniae DNA. PCR was performed as described by Tucker et al. 59.2% of children from the study group were Ch. pneumoniae positive. The presence of Ch. pneumoniae in the respiratory tract in children is relatively common. A significantly higher level of the carrier state exists in the families of active smokers and families. A with low living standard make a considerable contribution to environmental factors in the spread of HPV and Ch. pneumoniae co-infection.
The mucosa of the upper respiratory tract (URT) in children is a site where various pathogenes are likely to settle (8). Screening examinations have shown high (46.6%) Human papillomavirus (HPV) carrier state in the URT of healthy children. These findings have caused the authors to undertake further studies in a search for other pathogenes co-existing in URT epithelial cells. The chosen organism was Ch. pneumoniae. Chlamidia micro-organisms are a large group of hypokinetic obligatory intracellular parasites related to gram-negative bacteria, formerly classified as viruses (1). It was believed that the Chlamidia genus comprised two species: Ch. trachomatis - responsible for perinatal infections in neonates and children up to the 2nd year of life (2), and Ch. psittaci - a zoogenous pathogen. The third species - Ch. pneumoniae, a recognized causative agent of upper and lower respiratory infections, was identified in 1986 as a TWAR factor and was considered primarily a Ch. psittaci serotype. The species Ch. pneumoniae has been chosen for further studies because of its relationship to epithelial cells, and the non-symptomatic infections it causes. A significant feature of Chlamidia infections is a frequently noticed symbiosis between a host organism and a parasite. This may account for a long-term infection, sometimes for life (4, 5, 7).
Aim of the paper
The aim of the paper was to establish the level of the Ch. pneumoniae carrier state in the URT of healthy children who had formerly been diagnosed as having a non-symptomatic HPV infection. Moreover, the paper aims at establishing the transmission routes of such infections and identifying possible predisposing factors.
Materials and methods
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