© Borgis - Postępy Nauk Medycznych 12/2017, s. 729-730
The paper “Concentration of 25(OH)D3 in hospitalised patients with type 1 diabetes” by Małgorzata Godziejewska-Zawada and Paulina Surowiec is devoted to the evaluation of the levels of vitamin D3 in hospitalised patients with type 1 diabetes, as well as an analysis of the correlation between serum vitamin D3 levels and diabetes compensation as well as its seasonal variability. The authors demonstrated that vitamin D3 deficiency is common in hospitalised patients with type 1 diabetes – reaching an average of half of its recommended serum levels. Therefore, vitamin D3 supplementati on is indicated in patients with type 1 diabetes mellitus.
In the article “Prevention and treatment of steroid-induced osteoporosis – recommendations vs clinical practice”, Karolina Nowak presents a study whose aim was to evaluate whether patients chronically treated with glucocorticoids receive adequate prevention and treatment of glucocorticoid-induced osteoporosis, as in accordance with current Polish recommendations, as well as to investigate vitamin D deficiency in this population. The study clearly shows that patients chronically treated with glucocorticoids require more strict surveillance in terms of steroid-induced osteoporosis prevention (especially vitamin D supplementation) and treatment in order to prevent fractures and disability.
In the paper „Evaluation of factors affecting Quality of Life in acromegaly”, Stanisław Zgliczyński et al. present an evaluation of the quality of life in patients with acromegaly, based on the AcroQoL questionnaire. The author demonstrated that osteoarticular symptoms, respiratory dysfunctions and changes in the appearance are factors that have the greatest impact on the quality of life in these patients. Furthermore, the quality of life was significantly improved in professionally active individuals.
In their article entitled “The effect of the consumed meal and of serum sample freezing/thawing cycles on the chromogranin A (CgA) blood level”, Piotr Glinicki et al. discuss the results of a study which demonstrated no statistically significant differences in either postprandial CgA levels or after three consecutive freezing/thawing cycles. Although meals had no effects on serum CgA levels in most patients, the effect was significant in some cases; therefore it seems reasonable to use fasting blood specimens.
In the article “Marine-Lenhart syndrome”, Agnieszka Majos et al. described a case of a 40-year-old woman with a history of autonomous thyroid nodule and seven years of symptoms of severe hyperthyroidism in the course of Graves’ disease. The author also presented the diagnostic process and treatment strategy, as well as analysed other cases of Marine-Lenhart syndrome reported in the literature, pointing out that the diagnosis of the syndrome may be difficult due to variations in the scintigraphic picture of the nodules and thyroid parenchyma. The author concludes that close clinical follow-up combined with an assessment of serum anti-TSH receptor antibodies and thyroid imaging procedures, such as scintigraphy and ultrasonography, are necessary for the proper diagnosis and an appropriate treatment strategy.
A review paper by Małgorzata Gietka-Czernel et al., whish is entitled “Multiple endocrine neoplasia type 1”, discusses the causes, course and treatment of the disease in question. Untreated patients die by the age of 50 years, with malignant neuroendocrine tumour of the pancreas or thymus being the main cause of death. The management of patients with MEN1 may be challenging. Permanent surveillance with periodic biochemical and radiological screening is needed in these patients and their first-degree relatives who are carriers of MEN1 mutations.
The article “Impairment of male fertility – a consequential problem of our time. The impact of obesity and related metabolic disorders” by Jarosław Kozakowski and Piotr Dudek is devoted to the impact of obesity and type 2 diabetes on the hormonal control of spermatogenesis and the direct effects of these factors on the process of sperm production. Progressive deterioration of semen quality and damage to the genetic material (DNA) of germ cells is observed in these conditions.
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