© Borgis - New Medicine 4/2014, s. 136-138
*Konrad Wroński1,2, Zbigniew Masłowski2, Leszek Frąckowiak1,3, Zbigniew Kozielec4
Chromophobe renal cell carcinoma – case report and review of literature
1Department of Oncology, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland
Head of Department: prof. Sergiusz Nawrocki, MD, PhD
2Department of Surgical Oncology, Hospital Ministry of Internal Affairs with Warmia and Mazury Oncology Centre, Olsztyn, Poland
Head of Department: Andrzej Lachowski, MD
3Department of Gynecology and Gynecologic Oncology, Hospital Ministry of Internal Affairs with Warmia and Mazury Oncology Centre, Olsztyn, Poland
Head of Department: Leszek Frąckowiak, MD, PhD
4Department of Pathomorphology, Hospital Ministry of Internal Affairs with Warmia and Mazury Oncology Centre, Olsztyn, Poland
Head of Department: Zbigniew Kozielec, MD, PhD
Chromophobe renal cell carcinoma comprises about 5% of the total cases of renal cell carcinoma. This neoplasm is diagnosed in 6th decade of life. The incidence of chromophobe renal cell carcinoma is similar in male and female population. Prognosis of this type of renal carcinoma is better than in other types. The authors of this article presented a case of a 60-year-old Caucasian woman who was admitted to the hospital because of right kidney tumor. The patient two years ago was treated due to melanoma of the back. Therefore, there was suspicion of melanoma metastasis to the right kidney. The author performed a literature review on chromophobe renal cell carcinoma diagnosis and treatment.
Renal cell carcinoma is the most common neoplasm of the kidney (1, 2). This malignant neoplasm accounts about 2-3% of all cancers and in the most cases is diagnosed sporadic during imaging examinations such as ultrasonography and computer tomography (1-4). Chromophobe renal cell carcinoma comprises about 5% of the total cases of renal cell carcinoma (1, 2). This neoplasm is diagnosed in 6th decade of life (5, 6). The incidence of chromophobe renal cell carcinoma is similar in male and female population (1, 4, 6).
A 60-year-old Caucasian woman was referred to the Department of Surgical Oncology due to right kidney tumor which was incidentally examined in USG and CT scan (fig. 1). The size of this tumor in CT scan was 30 x 29 mm. The tumor was located in the middle of the right kidney cortex. In other organs of the abdomen and pelvic pathology has not been found in CT. In the interview, the patient reported no fever and pain. She had no any other symptoms, there was no history of weight loss and loss of appetite. The patient was treated for hypertension, ischemic heart disease and atherosclerosis. She had surgery two years ago due to melanoma of the back. There was no history of carcinoma in patient family.
Figure 1. Tumor of the right kidney diameter 30 mm.
On physical examination the abdomen was soft, painless, without symptoms of peritoneal. The hemoglobin level was 131 g/l, the red blood cell count was 4.79x1012/l and other routine hematological examinations and biochemical tests were within normal limits.
Considering the tumor was located in the right kidney and there was suspicion of melanoma metastasis, an open right nephrectomy was performed (fig. 2, 3). During a surgical procedure, there was no bleeding. Patient after surgery felt good and did not complain of pain. The postoperative period was uncomplicated and the patient left the ward in the 7th day after surgery.
Figure 2. Macroscopic view of chromophobe renal cell carcinoma diameter 30 mm.
Figure 3. Chromophobe renal cell carcinoma is macroscopically mostly single, well-demarcated tumor, color gray to brown, to cross solid, without necrosis and blood hemorrhage.
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